F

Fc-silencing is the minimization of the Fc-dependent recruitment of immune system cells through antibody-antigen complexes. Many promising therapeutic approaches rely on the mere inactivation of a biological process through antibody binding. In the past, these approaches were not feasible due to concomitant activation of the immune system, leading to adverse side effects. With the development […]

Fc receptors are found on the surface of several immune cells, e. g. B cells and natural killer cells (NK cells). They are bound and activated by the fragment crystallizable (Fc) region of antibodies. This interaction is the activating mechanism of ADCC, in which NK cells are strongly recruited by Fc regions with artificially low […]

The Fab region of an antibody contains the paratope and consists of part of one heavy and one light chains, specifically one constant region and one variable region. One Fab corresponds to one tip of an antibodies’ “Y”.