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Monospecific binding implies the specific binding of one epitope, cell or tissue type. The term describes a functional property of antibodies, but does not relate to the origin or production process. Monospecific antibodies may be produced from the same cell clone (i. e. monclonal antibodies) but this is not a necessary condition for monospecific binding.

Monomeric antibodies are present in the IgG, IgD, IgE isotype classes. IgA and IgM are oligomeric complexes that consist of more individual antibodies.

Monoclonal antibodies are antibodies that are virtually identical in their affinity and specificity against their antigen and bind one single epitope. They are generally produced by cells which originate from the same cell, hence share the same genetic material.

Mammalian cell lines are derived from mammals and can be grown in cell cultures. They are not as easily grown as simpler cell types, but the expressed antibodies are of much higher quality due to the native glycosylation pattern.