The design of your antibody sequence is the single most important step in your therapeutic development journey. Weak binding, off-target effects, and insufficient activity can all improve via sequence engineering. If you want to explore novel and innovative formats (e.g. bispecifics), then further sequence engineering is necessary to introduce new mutations, build new structures, and combine new binding domains.
Throughout 14 years of operations, we have performed >130,000 successful production runs of different antibodies and antibody related formats, covering different species, subtypes, and isotypes, as well as a range of novel and engineered assemblies. This depth of experience is available for all our clients to benefit from, on a royalty-free, fee-for-service basis. Whether you need to create a murine analogue of your human IgG1 therapeutic for in vivo work, or want to stitch together different variable domains with a novel backbone, evitria’s scientists are ready and willing to guide you through the design choices and share lessons learnt.
At evitria, the process always begins with the variable domains – once we establish these sequences, our modular cloning techniques enable rapid reassembly of your construct, whether a simple process (choosing from our library of >600 different constant domains) or a more bespoke design (such as the design of bi- and multi-specific antibodies).
Frequently, our clients need to enhance immune effector functions, enhancing ADCC or CDC. Here, we have experience producing all commercially-approved ADCC enhancing mutation sets, as well as generating afucosylated antibodies with the GlymaxX® technology, an unique approach to enhancing ADCC activity. For clients working within anti-inflammatory therapeutics, or with many bispecifics, abolishing immune effector functions may be needed. Here, we can provide silenced Fc domains, and we can guide clients through the pros and cons of working with each mutation set, including the fully silent STR technology.
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As soon as you begin a project with evitria, you can count on our team’s dedication and experience to guide the way – if you are thinking about where your variable domains can take you, why not just tell us where you want to go?