afucosylated-antibodies

Afucosylated antibodies for ADCC enhancement

Therapeutic antibodies with low fucose content demonstrate higher ADCC (Antibody-Dependent Cellular Cytotoxicity), i.e. elevated killing activity against tumorigenic and infected cells.

Artificially decreasing fucose content via afucosylation can enhance ADCC and thereby increase therapeutic effect, significantly reduce dosage requirements, and eventually result in fewer side effects.

evitria holds an exclusive licensing partnership to offer afucosylation via ProBioGen’s GlymaxX® technology for your transient antibody expression needs.

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GlymaxX® antibodies purified

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GlymaxX® projects completed

evitria uses
ProBioGen’s GlymaxX® technology

With the GlymaxX® platform, evitria can transiently express both native and afucosylated variants using the same CHO cells, the same DNA, and without any amino acid sequence modifications. In other words, we can provide the perfect negative control.

Whereas alternative afucosylation approaches rely on Fc mutations that introduce risk of immunogenicity, evitria’s use of GlymaxX® produces the same yields and stability as native antibodies without the danger of potential immune response.

How we work at evitria

project start - how we work at evitria

Project start

0-1 business days

pilot study (from electronic sequence to quantified pilot supernatant)

Pilot study

(from electronic sequence to quantified pilot supernatant)

15-20 business days

larger-scale expression - how we work at evitria

Larger-scale expression

5-10 business days

purification - how we work at evitria

Purification

2-3 business days

final analytics - how we work at evitria

Final analytics

2-3 business days

shipment - how we work at evitria

Shipment

1-2 business days

How to order with evitria

You tell us what you need and when

Optional: We discuss your project and how we might be able to assist in a personal conversation

You receive our proposal within one working day

You review and approve our proposal

Your project begins within one working day

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